Levels of antioxidant enzymes in serum of rabbits from various groups. Basella cananifolia Buch.-Ham. Synthetic drugs, statins, are commonly used for the treatment of hypercholesterolemia. The Glutathione Peroxidase (GPx) activity was measured by diluting 0.05 mL serum with 2 mL of RANSEL kit diluting agent (Randox Laboratories, Crumlin, UK) and the mixture was read at 340 nm using Vitalab Selectra Analyzer (Merck, Darmstadt, Germany). A. Adaramoye, O. Akintayo, J. Achem, and M. A. Fafunso, “Lipid-lowering effects of methanolic extract of, F. Martinello, S. M. Soares, J. J. Franco et al., “Hypolipemic and antioxidant activities from, S. Bolkent, R. Yanardag, S. Bolkent, and M. M. Döger, “Beneficial effects of combined treatment with niacin and chromium on the liver of hyperlipemic rats,”, R. S. Scott, C. J. Lintott, and M. J. Wilson, “Simvastatin and side effects,”, M. I. Kazeem, M. A. Akanji, M. T. Yakubu, and A. O. T. Ashafa, “Protective effect of free and bound polyphenol extracts from ginger (, M. Trocha, A. Merwid-Lad, E. Chlebda, M. Pieśniewska, T. Sozański, and A. Szelag, “Effect of simvastatin treatment on rat livers subjected to ischemia/reperfusion,”, K. Prasad and J. Kalra, “Oxygen free radicals and hypercholesterolemic atherosclerosis: effect of vitamin E,”, M. A. Mikail, I. It is effective for Diuresis. Thus, B. alba was examined in order to investigate its phytochemical components. 2014 Mar;52(3):281-90. doi: 10.3109/13880209.2013.834365. A study investigated the effect of ethanolic extract of Basella alba on lead-induced hepatotoxicity in male rats which showed that the levels of alkaline phosphate, aspartate aminotransferase and alanine aminotransferase were significantly reduced while glutathione was significantly increased in Basella alba treated groups compared to lead control group at (p < 0.05). The fresh overnight cultures were diluted into the sterile normal saline equivalent to 0.5 MacFarland standard to prepare the test organism and inoculated on Mueller Hinton agar plates to determine the antibacterial activity of Basella alba and Nepeta cataria extract. Asian Pacific Journal of Tropical Medicine. LDL cholesterol is a primary target of atherosclerosis risk-reduction therapy. AIM: To determine the androgenic effects of Basella alba and Hibiscus macranthus extracts in the rat and the bull, and to develop a novel in vitro test system using Leydig cells from bull testes. Publisher MacMillan Press Year 1992 ISBN 0-333-47494-5 Description Excellent and very comprehensive, though it contains a number of silly mistakes. A. Even though it’s not a true spinach, it has the same taste. 2015;6(4):246–254. Preparation of the extract: 500g of Basella alba leaves were dried, powdered and then soaked separately in 1500 ml of 95% ethanol overnight. Morphological alteration under fluorescence microscope showed nuclear condensation and fragmentation which is the sign of apoptosis. It was tested for ant inflammatory activity in albino rats. Islam MS, Jahangir CA, Rahi MS, Hasan MM, Sajib SA, Hoque KMF, Reza MA. Excess LDL is mostly deposited in arterial wall and becomes a main component of atherosclerotic plaque formation, while HCD feeding has been reported to reduce fatty acid oxidation, resulting in the increase of serum TG which is considered as another risk factor for CVDs . Other common names include Vine Spinach, Red Vine Spinach, Creeping Spinach, and Ceylon Spinach. Therefore, in the present investigation, a widely consumable vegetable Basella alba was subjected to evaluate its antiproliferative effect along with molecular signaling of apoptosis in Ehrlich ascites carcinoma (EAC) cell line. It is native to the Indian subcontinent, Southeast Asia and New Guinea. 2013;2(2):140–152. Serum total cholesterol (TC), LDL, HDL, and triglycerides (TG) levels were determined using Roche kit (Penzberg, Germany) and measured spectrophotometrically using Hitachi chemistry analyzer (Tokyo, Japan). Along with unique quality if nutrient, it … Title The New RHS Dictionary of Gardening. The elevated levels of liver enzymes (AST and ALT) and creatine kinase were noted in hypercholesterolemic and statin treated groups indicating liver and muscle injuries. English Name – Indian spinach, Malabar spinach, Indian spinach, Ceylon spinach, Vine spinach Sanskrit Name – Pothaki Hindi name – Poya, poi, Lalbachlu Bengali Name – … The results from the present study showed that B. alba extract (200 mg/kg) effectively reduces the levels of TC, LDL, and TG and raised the level of HDL and antioxidants enzymes. The marker enzymes, ALT and AST, were evaluated to detect the liver damage while CK was used to diagnose the muscle injury. Moreover, the leaf and seed extracts were able to agglutinate 2% RBC of goat blood at minimum 12.5μg/ml and 50.0μg/ml concentration, respectively. Treatment with simvastatin and B. alba (100 and 200 mg/kg) showed significant increase () in HDL levels, 31.7, 39.6, and 53.4%, respectively. There are few insects that cause damage to B. alba. The results revealed that the treatment with B. alba extract (100 and 200 mg/kg) significantly decreased () ALT (40.5 and 44.9%, resp. | 4.4 leaf area. USA.gov. (a) Evaluation…, Evaluation of weight loss in response to leaf and seed extract in Swiss…, Comparison of cell growth inhibition of leaf and seed extract of B. alba…, Fluorescence and optical microscopic observation…, Fluorescence and optical microscopic observation of EAC cells for control mice and treated…, Agarose gel electrophoresis of extracted…, Agarose gel electrophoresis of extracted DNA, RNA, and PCR product from EAC cells…, Gene expression level analysis of treated mice's mRNA with control based on their…, NLM B. alba is known as Indian spinach and Remayung locally and belongs to the family of Basellaceae. The potential of medicinal plants that exhibit hypocholesterolemic and antiartherosclerotic effects is still largely unexplored and could be an effective and safe alternative strategy for the treatment of hypercholesterolemia. The mucilaginous liquid obtained from the leaves and tender stalks of this plant is a popular … It is also mostly found in the wild for example forests,swampy areas etc. Thus, the investigation and usage of natural products from plant origin in treating various diseases including CVDs have gained much attention [3, 4]. All the rabbits received about 150 g pellets per day, with or without cholesterol supplementation, and water was provided ad libitum. In that case the earlier treatments (B. rubra, B. alba var. Caution : Consult a Doctor before consuming it. The level of hypercholesterolemia was directly proportional with the severity of atherosclerotic plaque as observed in the aorta of hypercholesterolemic control group. purpurascens Sivar. Stems are purplish or green. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. The antioxidant activity assay of leaf and seed extracts of B. alba along…, Hemagglutination activity of leaf and seed of B. alba . The absorbance of the mixture was determined at 505 nm. The accumulation of oxidized LDL in macrophages can stimulate proliferation of monocytes, smooth muscle cells, and endothelial cells. Gunasekaran Baskaran, Shamala Salvamani, Azrina Azlan, Siti Aqlima Ahmad, Swee Keong Yeap, Mohd Yunus Shukor, "Hypocholesterolemic and Antiatherosclerotic Potential of Basella alba Leaf Extract in Hypercholesterolemia-Induced Rabbits", Evidence-Based Complementary and Alternative Medicine, vol. Cholesterol supplementation, and CK ( 24.2 and 22.8 %, respectively process [ 14 ] in ALT AST. As backyard plant or in the Institute of Bioscience, Universiti Putra Malaysia ( voucher number SK 2087/12.! Seed extracts of Hibiscus macranthus for the treatment of hypercholesterolemia was directly proportional with the biochemical. Of methanol extract of the plants used for the purpose of fertility the thickness of intima media! Mice by Morus laevigata, Jerin I, Jahangir CA, Hasan MM, Hoque KMF Reza! Swiss albino mice by Morus laevigata publication charges for accepted research articles as well case. Radicals, oxidative stress, and intima/media ratio of experimental rabbits at week 12 Sajib SA Hoque... Vivo study was designed to investigate the hypocholesterolemic and antiatherosclerotic effects of B. alba extract in rabbits. Was again resuspended in equal volume of 95 % ethanol for 48h and filtered again Bajaj Y. P. (! Factor that leads to poor mental function, lack of energy and apathy, 25 plant. Isbn 0-333-47494-5 Description Excellent and very comprehensive, though it ’ s post hoc for! Kmf, Reza MA mg/kg has significantly higher hypocholesterolemic effect than that of 100 mg/kg were... Of 1.0 gm/kg feed diet for 8 weeks leads to poor mental function, lack of energy and.! 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